The fusion protein of HSP65 with tandem repeats of beta-hCG acting as a potent tumor vaccine in suppressing hepatocarcinoma.

@article{Xiangbing2010TheFP,
  title={The fusion protein of HSP65 with tandem repeats of beta-hCG acting as a potent tumor vaccine in suppressing hepatocarcinoma.},
  author={Hu Xiangbing and Zhang Yankai and Lin Ming and Lu Yong and Zhang Yu and Zhang Huiyong and Chen Yingying and Hou Jing and Xing Yun and Jin Liang and Cao Rongyue and Liu Jingjing},
  journal={International immunopharmacology},
  year={2010},
  volume={10 2},
  pages={230-8}
}
It has been demonstrated that the beta-subunit of human chorionic gonadotropin (beta-hCG) is ectopically expressed on a variety of human cancers of different histological types and has been used as an antigenic target in anti-cancer vaccines. We engineered a fusion protein by fusing 10 tandemly repeated copies of the 10-residue sequence of beta-hCG (109-118) (in CTP37) combined with beta-hCG C-terminal 37 peptides to mycobacterial heat-shock protein 65 and immunized mice via subcutaneous… CONTINUE READING

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