The fusion oncoprotein PML-RARalpha induces endoplasmic reticulum (ER)-associated degradation of N-CoR and ER stress.

Abstract

PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha), causes acute promyelocytic leukemias (APL). Although the role of nuclear PML-RARalpha has been extensively studied, a significant amount of PML-RARalpha is in the cytoplasm. The role cytoplasmic PML-RARalpha plays in leukemogenesis is unknown… (More)

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@article{Khan2004TheFO, title={The fusion oncoprotein PML-RARalpha induces endoplasmic reticulum (ER)-associated degradation of N-CoR and ER stress.}, author={Md Matiullah Khan and Teruaki Nomura and Tomoki Chiba and Keiji Tanaka and Hiderou Yoshida and Kazutoshi Mori and Shunsuke Ishii}, journal={The Journal of biological chemistry}, year={2004}, volume={279 12}, pages={11814-24} }