The fusion of membranes and vesicles: pathway and energy barriers from dissipative particle dynamics.

@article{Grafmller2009TheFO,
  title={The fusion of membranes and vesicles: pathway and energy barriers from dissipative particle dynamics.},
  author={Andrea Grafm{\"u}ller and Julian C. Shillcock and Reinhard Lipowsky},
  journal={Biophysical journal},
  year={2009},
  volume={96 7},
  pages={2658-75}
}
The fusion of lipid bilayers is studied with dissipative particle dynamics simulations. First, to achieve control over membrane properties, the effects of individual simulation parameters are studied and optimized. Then, a large number of fusion events for a vesicle and a planar bilayer are simulated using the optimized parameter set. In the observed fusion pathway, configurations of individual lipids play an important role. Fusion starts with individual lipids assuming a splayed tail… CONTINUE READING
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