The furan fatty acid metabolite CMPF is elevated in diabetes and induces β cell dysfunction.

@article{Prentice2014TheFF,
  title={The furan fatty acid metabolite CMPF is elevated in diabetes and induces β cell dysfunction.},
  author={Kacey J. Prentice and Lemieux Luu and Emma M. Allister and Ying Liu and Lucy S. Jun and Kyle W Sloop and Alexandre B. Hardy and Li Wei and Weiping Jia and Ivan George Fantus and Douglas H. Sweet and G. J. Sweeney and Ravi Retnakaran and Feihan F. Dai and Michael B Wheeler},
  journal={Cell metabolism},
  year={2014},
  volume={19 4},
  pages={653-66}
}
Gestational diabetes (GDM) results from failure of the β cells to adapt to increased metabolic demands; however, the cause of GDM and the extremely high rate of progression to type 2 diabetes (T2D) remains unknown. Using metabolomics, we show that the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) is elevated in the plasma of humans with GDM, as well as impaired glucose-tolerant and T2D patients. In mice, diabetic levels of plasma CMPF induced glucose… CONTINUE READING
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