The fungus Pestalotiopsis guepini as a model for biotransformation of ciprofloxacin and norfloxacin

@article{Parshikov2001TheFP,
  title={The fungus Pestalotiopsis guepini as a model for biotransformation of ciprofloxacin and norfloxacin},
  author={I. Parshikov and T. Heinze and J. Moody and J. Freeman and A. Williams and J. Sutherland},
  journal={Applied Microbiology and Biotechnology},
  year={2001},
  volume={56},
  pages={474-477}
}
Abstract. The metabolism of the fluoroquinolone drugs ciprofloxacin and norfloxacin by Pestalotiopsis guepini strain P-8 was investigated. Cultures were grown at 28 °C in sucrose/peptone broth for 18 days after dosing with ciprofloxacin (300 µM) or norfloxacin (313 µM). Four major metabolites were produced from each drug; and these were purified by high-performance liquid chromatography and identified by mass spectrometry and proton nuclear magnetic resonance spectroscopy. Ciprofloxacin… Expand
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