The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

@inproceedings{Kasper2018TheFP,
  title={The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes},
  author={Lydia Kasper and Annika K{\"o}nig and Paul-Albert Koenig and Mark S Gresnigt and Johannes Westman and Rebecca A Drummond and Michail S Lionakis and Olaf Gross and Juergen Ruland and Julian R Naglik and Bernhard Hube},
  booktitle={Nature Communications},
  year={2018}
}
Clearance of invading microbes requires phagocytes of the innate immune system. However, successful pathogens have evolved sophisticated strategies to evade immune killing. The opportunistic human fungal pathogen Candida albicans is efficiently phagocytosed by macrophages, but causes inflammasome activation, host cytolysis, and escapes after hypha formation. Previous studies suggest that macrophage lysis by C. albicans results from early inflammasome-dependent cell death (pyroptosis), late… CONTINUE READING

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