The fungal etiology of gout and hyperuricemia: the antifungal mode of action of colchicine

  title={The fungal etiology of gout and hyperuricemia: the antifungal mode of action of colchicine},
  author={A V Costantini},
  journal={Biomedical Reviews},
The concept of a fungal/mycotoxin etiology of gout/hyperuricemia in humans was first reported by Costantini in 1989. Gout and/or hyperuricemia have been induced in animals by the fungal species Ustilago maydis, Chaetomium trilaterale, Saccharomyces cerevisiae, and by the mycotoxins, aflatoxin, ochratoxin, oosporein, oxalic acid. Gout and/or hyperuricemia have been induced in humans by the yeast Candida utilis and by the fungal metabolites cyclosporin, ergotamine and penicillin. Gout is… 

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