The fundamental flaws of immunoassays and potential solutions using tandem mass spectrometry.

@article{Hoofnagle2009TheFF,
  title={The fundamental flaws of immunoassays and potential solutions using tandem mass spectrometry.},
  author={Andrew N Hoofnagle and Mark H. Wener},
  journal={Journal of immunological methods},
  year={2009},
  volume={347 1-2},
  pages={3-11}
}
Immunoassays have made it possible to measure dozens of individual proteins and other analytes in human samples for help in establishing the diagnosis and prognosis of disease. In too many cases the results of those measurements are misleading and can lead to unnecessary treatment or missed opportunities for therapeutic interventions. These cases stem from problems inherent to immunoassays performed with human samples, which include a lack of concordance across platforms, autoantibodies, anti… CONTINUE READING

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