The functions of mammalian amyloid precursor protein and related amyloid precursor-like proteins.

Abstract

It is well established that proteolytic processing of the beta-amyloid precursor protein (APP) generates beta-amyloid which plays a central role in the pathogenesis of Alzheimer's disease. In contrast, the physiological role of APP and the question of whether a loss of these functions contributes to Alzheimer's disease are still unclear. For a long time… (More)

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@article{Anliker2006TheFO, title={The functions of mammalian amyloid precursor protein and related amyloid precursor-like proteins.}, author={Brigitte Anliker and Ulrike Mueller}, journal={Neuro-degenerative diseases}, year={2006}, volume={3 4-5}, pages={239-46} }