The functions of endogenous C1q, a subcomponent of the first component of complement, as a receptor on the membrane of macrophages.

@article{Loos1982TheFO,
  title={The functions of endogenous C1q, a subcomponent of the first component of complement, as a receptor on the membrane of macrophages.},
  author={Michael D. Loos},
  journal={Molecular immunology},
  year={1982},
  volume={19 10},
  pages={
          1229-38
        }
}
C1q, the Fc-recognizing subcomponent of the first component of complement is synthesized by peritoneal macrophages. During the secretion phase C1q serves as an Fc-binding protein in the membrane of macrophages. The Fc-mediated rosette formation was inhibited in a dose-dependent manner when macrophages were pretreated with anti-C1q F(ab')2, whereas C3b rosette formation was not affected. Furthermore, preincubation of peritoneal macrophages with anti-C1q F(ab')2 abolished, dose- and time… CONTINUE READING
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