The functions and regulation of the PTEN tumour suppressor

  title={The functions and regulation of the PTEN tumour suppressor},
  author={Min Sup Song and L Salmena and Pier Paolo Pandolfi},
  journal={Nature Reviews Molecular Cell Biology},
The importance of the physiological function of phosphatase and tensin homologue (PTEN) is illustrated by its frequent disruption in cancer. By suppressing the phosphoinositide 3-kinase (PI3K)–AKT–mammalian target of rapamycin (mTOR) pathway through its lipid phosphatase activity, PTEN governs a plethora of cellular processes including survival, proliferation, energy metabolism and cellular architecture. Consequently, mechanisms regulating PTEN expression and function, including transcriptional… CONTINUE READING
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