The functionally antagonistic POU family transcription factors Brr‐3a and Brn‐3b show opposite changes in expression during the growth arrest and differentiation of human neuroblastoma cells

@article{Smith1996TheFA,
  title={The functionally antagonistic POU family transcription factors Brr‐3a and Brn‐3b show opposite changes in expression during the growth arrest and differentiation of human neuroblastoma cells},
  author={M. Smith and D. Latchman},
  journal={International Journal of Cancer},
  year={1996},
  volume={67}
}
  • M. Smith, D. Latchman
  • Published 1996
  • Biology, Medicine
  • International Journal of Cancer
  • The Brn‐3a and Brn‐3b POU family transcription factors have previously been shown to have functionally antagonistic effects, with Brn‐3a activating specific gene promoters which are repressed by Brn‐3b. We show here that proliferating cell lines of human neuroblastoma origin have a high ratio of Brn‐3b to Brn‐3a compared with other cell lines derived from related tumours. Moreover, the level of Brn‐3a rises and that of Brn‐3b falls when neuroblastoma cell lines are exposed to treatments which… CONTINUE READING
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