The functional significance of cell clusters in the notochordal nucleus pulposus: survival and signaling in the canine intervertebral disc.

@article{Hunter2004TheFS,
  title={The functional significance of cell clusters in the notochordal nucleus pulposus: survival and signaling in the canine intervertebral disc.},
  author={Christopher J Hunter and John R Matyas and Neil A. Duncan},
  journal={Spine},
  year={2004},
  volume={29 10},
  pages={1099-104}
}
STUDY DESIGN Cell viability was assessed in relation to cell clustering, and mechanisms of cell-cell signaling in the clusters were investigated. OBJECTIVES To explore the functional role of cell clustering in the notochordal nucleus pulposus. SUMMARY OF BACKGROUND DATA The intervertebral disc of some species contains residual cells from the embryonic notochord. These cells form large three-dimensional clusters in the young, healthy disc but are replaced by chondrocyte-like cells during… CONTINUE READING

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