The functional significance behind expressing two IL-8 receptor types on PMN.

@article{Stillie2009TheFS,
  title={The functional significance behind expressing two IL-8 receptor types on PMN.},
  author={RoseMarie Stillie and Shukkur Muhammed Farooq and John R. M. Gordon and Andrew W. Stadnyk},
  journal={Journal of leukocyte biology},
  year={2009},
  volume={86 3},
  pages={529-43}
}
PMN are critical to innate immunity and are fundamental to antibacterial defense. To localize to sites of infection, PMN possess receptors that detect chemoattractant stimuli elicited at the site, such as chemokines, complement split products, or bioactive lipids. Signaling through these receptors stimulates chemotaxis toward the site of infection but also activates a number of biochemical processes, with the result that PMN kill invading bacteria. PMN possess two receptors, CXCR1 and CXCR2… CONTINUE READING