The functional promoter polymorphism of the coagulation factor XII gene is not associated with peripheral arterial disease.

Abstract

Coagulation factor XII (FXII) plays a key role in both coagulation and fibrinolysis and has been associated with cardiovascular disease in some studies. Plasma FXIIa levels are strongly determined by a common functional polymorphism in the promoter of the FXII gene (F12-4C>T). To investigate the potential association of this polymorphism with peripheral… (More)
DOI: 10.1177/0003319709337305

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