The functional polymorphism of the hemoglobin‐binding protein haptoglobin influences susceptibility to idiopathic Parkinson's disease

@article{CostaMallen2008TheFP,
  title={The functional polymorphism of the hemoglobin‐binding protein haptoglobin influences susceptibility to idiopathic Parkinson's disease},
  author={P. Costa-Mallen and H. Checkoway and A. Zabeti and Michael J Edenfield and P. Swanson and W. Longstreth and G. Franklin and Terri Smith-Weller and S. M. Sadrzadeh},
  journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics},
  year={2008},
  volume={147B}
}
Oxidative stress and iron have been widely implicated in the etiology of Parkinson's disease (PD). Hemoglobin is the richest source of iron in the body. The human Haptoglobin (Hp) protein is a plasma alpha‐2 glycoprotein that removes free Hemoglobin from the circulation and tissues and is important in protection from oxidative stress, in immune system regulation, and angiogenesis. A common genetic polymorphism of Hp exists in the population, where the Hp 1‐1, Hp 2‐1, and Hp 2‐2 forms exhibit… Expand

Paper Mentions

Observational Clinical Trial
This is a case/control epidemiology study to identify what are the iron-metabolism abnormalities in Parkinson's disease (PD) patients, and risk factors relevant to PD… Expand
ConditionsParkinson's Disease
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