The functional interactions of commensal bacteria with intestinal secretory IgA

@article{Macpherson2007TheFI,
  title={The functional interactions of commensal bacteria with intestinal secretory IgA},
  author={Andrew J. Macpherson and Emma Slack},
  journal={Current Opinion in Gastroenterology},
  year={2007},
  volume={23},
  pages={673–678}
}
Purpose of review The aim of this article is to describe the immune geography of IgA induction by commensal intestinal bacteria and the underlying mechanisms of cytokine and costimulatory signalling between dendritic cells, B cells and T cells. Recent findings Intestinal dendritic cells sample commensal intestinal bacteria that penetrate the epithelial layer and induce IgA+ B cells to seed the mucosa with IgA plasma cells. Constitutive secretion of retinoic acid by intestinal dendritic cells… Expand
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