The functional importance of the extreme C-terminal tail in the gene 2 organellar Ca(2+)-transport ATPase (SERCA2a/b).

@article{Verboomen1994TheFI,
  title={The functional importance of the extreme C-terminal tail in the gene 2 organellar Ca(2+)-transport ATPase (SERCA2a/b).},
  author={H Verboomen and Frank Wuytack and Ludo Van Den Bosch and Liesbet Mertens and Rik Casteels},
  journal={The Biochemical journal},
  year={1994},
  volume={303 ( Pt 3)},
  pages={979-84}
}
Ca(2+)-uptake experiments in microsomal fractions from transfected COS-1 cells have revealed a functional difference between the non-muscle SERCA2b Ca2+ pump and its muscle-specific SERCA2a splice variant. Structurally, the two pumps differ only in their C-terminal tail. The last four amino acids of SERCA2a are replaced in SERCA2b by a 49-residue-long peptide chain containing a very hydrophobic stretch which could be an additional transmembrane segment. The functionally important subdomains in… CONTINUE READING

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