The functional heterogeneity of eosinophil cationic protein is determined by a gene polymorphism and post‐translational modifications

@article{Trulson2007TheFH,
  title={The functional heterogeneity of eosinophil cationic protein is determined by a gene polymorphism and post‐translational modifications},
  author={A. Trulson and J. Bystr{\"o}m and A. Engström and R. Larsson and P. Venge},
  journal={Clinical \& Experimental Allergy},
  year={2007},
  volume={37}
}
Background The eosinophil is a cytotoxic cell and takes part in parasite killing and tissue‐destructive processes by secretion of proteins such as eosinophil cationic protein (ECP). A polymorphism was demonstrated in the ECP gene, giving rise to a substitution of arginine at position 97 with threonine. This polymorphism is related to disease development. 
A SELDI‐TOF MS study of the genetic and post‐translational molecular heterogeneity of eosinophil cationic protein
The production of the eosinophil proteins ECP and EPX/EDN are regulated in a reciprocal manner
Asparagine-linked glycans determine the cytotoxic capacity of eosinophil cationic protein (ECP).
The 434(G>C) polymorphism within the coding sequence of Eosinophil Cationic Protein (ECP) correlates with the natural course of Schistosoma mansoni infection.
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The cytotoxic eosinophil cationic protein (ECP) has ribonuclease activity.
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