The functional genomic distribution of protein divergence in two animal phyla: coevolution, genomic conflict, and constraint.

@article{CastilloDavis2004TheFG,
  title={The functional genomic distribution of protein divergence in two animal phyla: coevolution, genomic conflict, and constraint.},
  author={Cristian I. Castillo-Davis and Fyodor A. Kondrashov and Daniel L. Hartl and Rob J Kulathinal},
  journal={Genome research},
  year={2004},
  volume={14 5},
  pages={802-11}
}
We compare the functional spectrum of protein evolution in two separate animal lineages with respect to two hypotheses: (1) rates of divergence are distributed similarly among functional classes within both lineages, indicating that selective pressure on the proteome is largely independent of organismic-level biological requirements; and (2) rates of divergence are distributed differently among functional classes within each lineage, indicating species-specific selective regimes impact genome… CONTINUE READING
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