The functional domains of the Drosophila morphogen dorsal: evidence from the analysis of mutants.

@article{Isoda1992TheFD,
  title={The functional domains of the Drosophila morphogen dorsal: evidence from the analysis of mutants.},
  author={Kei Isoda and Siegfried Roth and C N{\"u}sslein-volhard},
  journal={Genes & development},
  year={1992},
  volume={6 4},
  pages={619-30}
}
The dorsal (dl) protein is a member of the Rel family of transcription factors. It is distributed in a nuclear concentration gradient along the dorsoventral axis of Drosophila embryos and activates or represses a discrete set of zygotic genes in a concentration-dependent manner. The nuclear uptake of the dl protein is stimulated by products of the dorsal group genes but inhibited by the cactus (cact) product. To analyze the functional domains of the dl protein, we sequenced 11 dl alleles and… CONTINUE READING

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