The functional divergence of short-chain dehydrogenases involved in tropinone reduction.

@article{Brock2008TheFD,
  title={The functional divergence of short-chain dehydrogenases involved in tropinone reduction.},
  author={Andrea Brock and Wolfgang Brandt and Birgit Dr{\"a}ger},
  journal={The Plant journal : for cell and molecular biology},
  year={2008},
  volume={54 3},
  pages={
          388-401
        }
}
Tropane alkaloids typically occur in the Solanaceae and are also found in Cochlearia officinalis, a member of the Brassicaceae. Tropinone reductases are key enzymes of tropane alkaloid metabolism. Two different tropinone reductases form one stereoisomeric product each, either tropine for esterified alkaloids or pseudotropine that is converted to calystegines. A cDNA sequence with similarity to known tropinone reductases (TR) was cloned from C. officinalis. The protein was expressed in… 

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