The functional antagonist Met-RANTES: A modified agonist that induces differential CCR5 trafficking

@article{Kiss2009TheFA,
  title={The functional antagonist Met-RANTES: A modified agonist that induces differential CCR5 trafficking},
  author={Debra L. Kiss and James Longden and Gregory A. Fechner and Vicky M. Avery},
  journal={Cellular & Molecular Biology Letters},
  year={2009},
  volume={14},
  pages={537-547}
}
CC chemokine receptor 5 (CCR5) is a pro-inflammatory chemokine receptor that is expressed on cells of the immune system, and specializes in cell migration in response to inflammation and tissue damage. Due to its key role in cell communication and migration, this receptor is involved in various inflammatory and autoimmune diseases, in addition to HIV infection. Met-RANTES is a modified CCR5 ligand that has previously been shown to antagonize CCR5 activation and function in response to its… CONTINUE READING

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