The functional annotation of mammalian genomes: the challenge of phenotyping.

@article{Brown2009TheFA,
  title={The functional annotation of mammalian genomes: the challenge of phenotyping.},
  author={Steve D M Brown and Wolfgang Wurst and Ralf K{\"u}hn and John M. Hancock},
  journal={Annual review of genetics},
  year={2009},
  volume={43},
  pages={305-33}
}
The mouse is central to the goal of establishing a comprehensive functional annotation of the mammalian genome that will help elucidate various human disease genes and pathways. The mouse offers a unique combination of attributes, including an extensive genetic toolkit that underpins the creation and analysis of models of human disease. An international effort to generate mutations for every gene in the mouse genome is a first and essential step in this endeavor. However, the greater challenge… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Hearing loss: mechanisms revealed by genetics and cell biology.

Annual review of genetics • 2009
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 147 references

Inductive Logic Programming

Lecture Notes in Computer Science • 2011
View 1 Excerpt

Questioning standardization in science

Nature Methods • 2009
View 1 Excerpt

CASIMIR: Coordination and Sustainability of International Mouse Informatics Resources

2008 8th IEEE International Conference on BioInformatics and BioEngineering • 2008
View 1 Excerpt

Chromosomal transposition of PiggyBac in mouse embryonic stem cells.

Proceedings of the National Academy of Sciences of the United States of America • 2008
View 1 Excerpt

Similar Papers

Loading similar papers…