The functional annotation of mammalian genomes: the challenge of phenotyping.

  title={The functional annotation of mammalian genomes: the challenge of phenotyping.},
  author={Steve D M Brown and Wolfgang Wurst and Ralf K{\"u}hn and John M. Hancock},
  journal={Annual review of genetics},
The mouse is central to the goal of establishing a comprehensive functional annotation of the mammalian genome that will help elucidate various human disease genes and pathways. The mouse offers a unique combination of attributes, including an extensive genetic toolkit that underpins the creation and analysis of models of human disease. An international effort to generate mutations for every gene in the mouse genome is a first and essential step in this endeavor. However, the greater challenge… CONTINUE READING

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