The functional SNP in the matrix metalloproteinase-3 promoter modifies susceptibility and lymphatic metastasis in esophageal squamous cell carcinoma but not in gastric cardiac adenocarcinoma.

@article{Zhang2004TheFS,
  title={The functional SNP in the matrix metalloproteinase-3 promoter modifies susceptibility and lymphatic metastasis in esophageal squamous cell carcinoma but not in gastric cardiac adenocarcinoma.},
  author={Jianhui Zhang and Xia Jin and Shumei Fang and Yan Li and Rui Wang and Wei Guo and Na Wang and Yimin Wang and Denggui Wen and Lizhen Wei and Gang Kuang and Zhiming Dong},
  journal={Carcinogenesis},
  year={2004},
  volume={25 12},
  pages={2519-24}
}
The matrix metalloproteinases (MMPs), a family of proteolytic enzymes that degrade different components of the extracellular matrix, play important roles in tumor development and invasion. A single adenine insertion/deletion polymorphism (6A/5A) in the MMP3 promoter region causes transcriptional elevation. The aim of this study was to assess the effects of this single nucleotide polymorphism (SNP) on the development and clinical staging of esophageal squamous cell carcinoma (ESCC) and gastric… CONTINUE READING
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