The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy.

@article{Prudente2005TheFQ,
  title={The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy.},
  author={Sabrina Prudente and Marta Letizia Hribal and Elisabetta Flex and Federica Turchi and Eleonora Morini and Salvatore De Cosmo and Simonetta Bacci and Vittorio Tassi and Marina Cardellini and Renato Lauro and Giorgio Sesti and Bruno Dallapiccola and Vincenzo Trischitta},
  journal={Diabetes},
  year={2005},
  volume={54 9},
  pages={2807-11}
}
Insulin resistance plays a major role in dyslipidemia, cardiovascular disease, and type 2 diabetes. TRB3, a mammalian tribbles homolog, whose chromosomal region 20p13-p12 has been linked to human type 2 diabetes, impairs insulin signaling through the inhibition of Akt phosphorylation and is overexpressed in murine models of insulin resistance. We here report that the prevalent TRB3 missense Q84R polymorphism is significantly (P < 0.05) associated with several insulin resistance-related… CONTINUE READING