The functional BDNF Val66Met polymorphism affects functions of pre-attentive visual sensory memory processes

@article{Beste2011TheFB,
  title={The functional BDNF Val66Met polymorphism affects functions of pre-attentive visual sensory memory processes},
  author={Christian Beste and Daniel Schneider and J{\"o}rg T. Epplen and Larissa Arning},
  journal={Neuropharmacology},
  year={2011},
  volume={60},
  pages={467-471}
}

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References

SHOWING 1-10 OF 44 REFERENCES

Ebbinghaus Revisited: Influences of the BDNF Val66Met Polymorphism on Backward Serial Recall Are Modulated by Human Aging

Findings indicate that effects of the BDNF polymorphism on episodic memory are most likely to be observed when the associative and executive demands are high, in line with the hypothesis that the magnitude of genetic effects on cognition is greater when brain resources are reduced, as is the case in old age.

Variation in brain-derived neurotrophic factor (BDNF) gene is associated with symptoms of depression.

Genetic Variant BDNF (Val66Met) Polymorphism Alters Anxiety-Related Behavior

A variant BDNF mouse (BDNFMet/Met) is generated that reproduces the phenotypic hallmarks in humans with the variant allele and may play a key role in genetic predispositions to anxiety and depressive disorders.

Association of a functional BDNF polymorphism and anxiety-related personality traits

The hypothesis that anxiety- and depression-related personality traits are associated with the BDNF polymorphism although the explained variance is low is supported.

Association between BDNF Val66Met polymorphism and trait depression is mediated via resting EEG alpha band activity

The Role of the BDNF Val66Met Polymorphism for the Synchronization of Error-Specific Neural Networks

The results suggest that alterations in neural synchronization processes modulated by the genetic variants of BDNF Val66Met may be the mechanism by which cognitive functions are affected in situations requiring behavioral adaptation.

Is it time to reassess the BDNF hypothesis of depression?

  • J. Groves
  • Biology, Psychology
    Molecular Psychiatry
  • 2007
A critical review of the clinical and preclinical studies which have been responsible for the controversy over the BDNF hypothesis of depression, outlining pharmacological, behavioural and genetic evidence which demonstrates the contrasting role of BDNF in regulating mood and antidepressant effects throughout the brain.

Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons

Findings indicate that components of the regulated secretory machinery interacts specifically with a signal in the BDNF prodomain and that perturbations in BDNF trafficking may lead to selective impairment in CNS function.