The functional −1019C/G HTR1A polymorphism and mechanisms of fear

  title={The functional −1019C/G HTR1A polymorphism and mechanisms of fear},
  author={Benjamin Straube and A. Reif and Jochen Richter and Ulrike Lueken and Heinz Weber and Volker Arolt and Andreas Jansen and Peter Zwanzger and Katharina Domschke and Paul Pauli and Christhoph Konrad and Alexander L. Gerlach and Thorsten Lang and Thomas Fydrich and Georg W. Alpers and Andreas Str{\"o}hle and Andr{\'e} Wittmann and Bettina Pfleiderer and Hans-Ulrich Wittchen and Alfons O. Hamm and Jochen Deckert and Tilo Kircher},
  booktitle={Translational Psychiatry},
Serotonin receptor 1A gene (HTR1A) knockout mice show pronounced defensive behaviour and increased fear conditioning to ambiguous conditioned stimuli. Such behaviour is a hallmark of pathological human anxiety, as observed in panic disorder with agoraphobia (PD/AG). Thus, variations in HTR1A might contribute to neurophysiological differences within subgroups of PD/AG patients. Here, we tested this hypothesis by combining genetic with behavioural techniques and neuroimaging. In a clinical… CONTINUE READING
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