The function of the pleckstrin homology domain in BCR–ABL-mediated leukemogenesis

@article{Demehri2010TheFO,
  title={The function of the pleckstrin homology domain in BCR–ABL-mediated leukemogenesis},
  author={Shadmehr Demehri and Thomas O'Hare and Christopher A. Eide and Colton A Smith and Jeffrey W. Tyner and Brian J. Druker and Michael Werner Nikolaus Deininger},
  journal={Leukemia},
  year={2010},
  volume={24},
  pages={226-229}
}
cytokines (Figures 2a–c) and IgM (Figure 2d). In one patient (patient 103), previous exposure to 852A appeared to make drug-resistant tumor cells temporarily more sensitive to a vincristine-based chemotherapy regimen (Figure 1), supporting a possible chemo-sensitizing role for TLR-7 agonists in vivo. Despite these encouraging observations, 852A had only weak clinical efficacy on its own, which was disappointing in view of the expectations raised by the preliminary in vitro observations and… CONTINUE READING

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