The function of the ectodermal apical ridge and distinctive characteristics of adjacent distal mesoderm in the avian wing-bud.

  • John M. Cairns
  • Published 1975 in Journal of embryology and experimental morphology


Blocks of mesoderm about 0-1 mm in diameter were isolated from various regions of chick wing-buds of stages 17 through 22 and cultured individually, or sometimes in pairs, in microtest plate wells. Cell deaths had occurred after 10 h of culture in those explants that had come from the region associated with the thickest part of the ectodermal ridge, and… (More)


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