The function of spliceosome components in open mitosis.

  title={The function of spliceosome components in open mitosis.},
  author={Jennifer C. Hofmann and Alma Husedzinovic and Oliver J Gruss},
  volume={1 6},
Spatial separation of eukaryotic cells into the nuclear and cytoplasmic compartment permits uncoupling of DNA transcription from translation of mRNAs and allows cells to modify newly transcribed pre mRNAs extensively. Intronic sequences (introns), which interrupt the coding elements (exons), are excised ("spliced") from pre-mRNAs in the nucleus to yield mature mRNAs. This not only enables alternative splicing as an important source of proteome diversity, but splicing is also an essential… CONTINUE READING


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