The function of nitric oxide in wound repair: inhibition of inducible nitric oxide-synthase severely impairs wound reepithelialization.

@article{Stallmeyer1999TheFO,
  title={The function of nitric oxide in wound repair: inhibition of inducible nitric oxide-synthase severely impairs wound reepithelialization.},
  author={Birgit Stallmeyer and Heiko K{\"a}mpfer and N. Kolb and Josef Martin Pfeilschifter and S. P. Frank},
  journal={The Journal of investigative dermatology},
  year={1999},
  volume={113 6},
  pages={1090-8}
}
Recently, we demonstrated a large induction of inducible nitric oxide synthase (iNOS) during cutaneous wound repair. In this study, we established an in vivo model in mice to investigate the role of NO during the wound healing process. During excisional repair, mice were treated with L-N6-(1-iminoethyl)lysine (L-NIL), a selective inhibitor of iNOS enzymatic activity. Compared with control mice, L-NIL-treated animals were characterized by a severely impaired reepithelialization process, as the… CONTINUE READING