The function of multiple IκB : NF-κB complexes in the resistance of cancer cells to Taxol-induced apoptosis

The Rel/NF-κB transcription factors play a key role in the regulation of apoptosis and in tumorigenesis by controlling the expressions of specific genes. To determine the role of the constitutive activity of RelA in tumorigenesis, we generated pancreatic tumor cell lines that express a dominant negative mutant of IκBα (IκBαM). In this report, we show that… (More)