The function of leptin in nutrition, weight, and physiology.

@article{Friedman2002TheFO,
  title={The function of leptin in nutrition, weight, and physiology.},
  author={Jeffrey M. Friedman},
  journal={Nutrition reviews},
  year={2002},
  volume={60 10 Pt 2},
  pages={
          S1-14; discussion S68-84, 85-7
        }
}
  • J. Friedman
  • Published 1 October 2002
  • Biology
  • Nutrition reviews
Recent advances indicate that a robust physiologic system acts to maintain relative constancy of weight in mammals. A key component of this system is leptin. Leptin is an adipocyte hormone that functions as the afferent signal in a negative feedback loop regulating body weight. In addition, leptin functions as a key link between nutrition and the function of most, if not all other physiologic systems. When at their set point, individuals produce a given amount of leptin and in turn maintain a… 
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Maternal consumption of high-fat diet disturbs hypothalamic neuronal function in the offspring: implications for the genesis of obesity.
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There are a number of experimental and human studies showing that maternal consumption of high-fat diets during gestation increase the risk for obesity, diabetes, and other components of the metabolic syndrome in the offspring, and Eva Rother and her colleagues from the University Hospital of Cologne in Germany have evaluated the outcomes of maternal high-Fat feeding during gestation and lactation on hypothalamic gene expression in the daughters.
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Leptin’s physiologic role in cardiomyocyte structure and function is reviewed and how leptin deficiency or disrupted signaling may trigger cardiac functional and morphologic abnormalities are reviewed.
Leptin and hyperleptinemia - from friend to foe for cardiovascular function.
  • J. Ren
  • Biology, Medicine
    The Journal of endocrinology
  • 2004
TLDR
Speculation that leptin in the physiological range may serve as a physiological regulator of cardiovascular function whereas elevated plasma leptin levels may act as a pathophysiological trigger and/or marker for cardiovascular diseases due to tissue leptin resistance is prompted.
Leptin and hyperleptinemia – from friend to foe for cardiovascular function
TLDR
Speculation that leptin in the physiological range may serve as a physiological regulator of cardiovascular function whereas elevated plasma leptin levels may act as a pathophysiological trigger and/or marker for cardiovascular diseases due to tissue leptin resistance is prompted.
Leptin and hyperleptinemia – from friend to foe for cardiovascular function
TLDR
Speculation that leptin in the physiological range may serve as a physiological regulator of cardiovascular function whereas elevated plasma leptin levels may act as a pathophysiological trigger and/or marker for cardiovascular diseases due to tissue leptin resistance is prompted.
Leptin and hyperleptinemia – from friend to foe for cardiovascular function
TLDR
Speculation that leptin in the physiological range may serve as a physiological regulator of cardiovascular function whereas elevated plasma leptin levels may act as a pathophysiological trigger and/or marker for cardiovascular diseases due to tissue leptin resistance is prompted.
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References

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TLDR
It is proposed that regulation of the neuroendocrine system during starvation could be the main physiological role of leptin, and preventing the starvation-induced fall in leptin with exogenous leptin substantially blunts the changes in gonadal, adrenal and thyroid axes in male mice, and prevents the starve-induced delay in ovulation in female mice.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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