The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres.

@article{Rai2010TheFO,
  title={The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres.},
  author={Rekha Rai and Hong Zheng and Hua He and Ying Luo and Asha S Multani and Phillip B. Carpenter and Sandy Chang},
  journal={The EMBO journal},
  year={2010},
  volume={29 15},
  pages={2598-610}
}
Repair of DNA double-stranded breaks (DSBs) is crucial for the maintenance of genome stability. DSBs are repaired by either error prone non-homologous end-joining (NHEJ) or error-free homologous recombination. NHEJ precedes either by a classic, Lig4-dependent process (C-NHEJ) or an alternative, Lig4-independent one (A-NHEJ). Dysfunctional telomeres arising either through natural attrition due to telomerase deficiency or by removal of telomere-binding proteins are recognized as DSBs. In this… CONTINUE READING
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