The function of catalase-bound NADPH.

  title={The function of catalase-bound NADPH.},
  author={Henry N. Kirkman and Silvana Galiano and Gian Franco Gaetani},
  journal={The Journal of biological chemistry},
  volume={262 2},
Catalase (H2O2:H2O2 oxidoreductase, EC is of historical interest for having been the subject of some of the earliest investigations of enzymes. A feature of catalase that has been poorly understood for several decades, however, is the mechanism by which catalase remains active in the presence of its own substrate, hydrogen peroxide. We reported recently that catalase contains tightly bound NADPH. The present study with bovine and human catalase revealed that NADPH both prevents and… CONTINUE READING