The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP.

@article{Ghin2002TheFO,
  title={The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP.},
  author={Martine G{\'e}hin and Manuel Mark and Christine Dennefeld and Andr{\'e}e Di{\'e}rich and Hinrich Gronemeyer and Pierre Chambon},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 16},
  pages={5923-37}
}
Human TIF2 (hTIF2) is a member of the p160 family of nuclear receptor coactivators, which includes SRC-1 and p/CIP. Although the functions of hTIF2 and of its mouse homolog (GRIP1 or mTIF2) have been clearly established in vitro, their physiological role remains elusive. Here, we have generated mice lacking mTIF2/GRIP1 and examined their phenotype with a particular emphasis on reproductive functions. TIF2(-/-) mice are viable, but the fertility of both sexes is impaired. Male hypofertility is… CONTINUE READING

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