The function of PML in p53-dependent apoptosis

  title={The function of PML in p53-dependent apoptosis},
  author={Ailan Guo and P. Salomoni and Jianyuan Luo and A. Shih and S. Zhong and Wei Gu and P. Pandolfi},
  journal={Nature Cell Biology},
  • Ailan Guo, P. Salomoni, +4 authors P. Pandolfi
  • Published 2000
  • Biology, Medicine
  • Nature Cell Biology
  • The PML gene of acute promyelocytic leukaemia (APL) encodes a growth- and tumour-suppresor protein that is essential for several apoptotic signals. The mechanisms by which PML exerts its pro-apoptotic function are still unknown. Here we show that PML acts as a transcriptional co-activator with p53. PML physically interacts with p53 both in vitro and in vivo and co-localizes with p53 in the PML nuclear body (PML-NB). The co-activatory role of PML depends on its ability to localize in the PML-NB… CONTINUE READING
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