The function and synthesis of ribosomes

@article{Lafontaine2001TheFA,
  title={The function and synthesis of ribosomes},
  author={Denis L. J. Lafontaine and David Tollervey},
  journal={Nature Reviews Molecular Cell Biology},
  year={2001},
  volume={2},
  pages={514-520}
}
Structural analyses of the large and small ribosomal subunits have allowed us to think about how they work in more detail than ever before. The mechanisms that underlie ribosomal synthesis, translocation and catalysis are now being unravelled, with practical implications for the design of antibiotics. 

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References

SHOWING 1-10 OF 77 REFERENCES

Ribosome synthesis in Saccharomyces cerevisiae.

The recent, and often surprising, advances in the understanding of ribosome synthesis in the yeast Saccharomyces cerevisiae will underscore the unexpected complexity of eukaryotic ribosomes synthesis.

Atomic structures at last: the ribosome in 2000.

Structure of Functionally Activated Small Ribosomal Subunit

The small ribosomal subunit performs the decoding coding mechanism and its universality, and highlights of genetic information during translation, and shows known as well as newly detected folding and packing motifs.

Reconstitution of 50S Ribosomal Subunits from Dissociated Molecular Components

50S ribosomal subunits of Bacillus stearothermophilus have been reconstituted by incubating their RNA and protein components at high temperatures.

Mechanism of ribosomal peptide bond formation.

The mechanism of peptide bond synthesis constitutes a fundamental and long-debated question in molecular biology. For many years, ribosomologists championed a protein-based mechanism, similar to the

Structure of the 30S ribosomal subunit

The crystal structure of the 30S subunit from Thermus thermophilus, refined to 3 Å resolution, is reported, which will facilitate the interpretation in molecular terms of lower resolution structural data on several functional states of the ribosome from electron microscopy and crystallography.

Direct Visualization of A-, P-, and E-Site Transfer RNAs in the Escherichia coli Ribosome

The detailed arrangement of A- and P-site tRNAs inferred from this study allows localization of the sites for anticodon interaction and peptide bond formation on the ribosome.

Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

The functional implications of the high-resolution 30S crystal structure are described, and details of the interactions between the 30S subunit and its tRNA and mRNA ligands are inferred, which lead to a model for the role of the universally conserved 16S RNA residues A1492 and A1493 in the decoding process.
...