The function and synthesis of ribosomes

  title={The function and synthesis of ribosomes},
  author={Denis L. J. Lafontaine and David Tollervey},
  journal={Nature Reviews Molecular Cell Biology},
Structural analyses of the large and small ribosomal subunits have allowed us to think about how they work in more detail than ever before. The mechanisms that underlie ribosomal synthesis, translocation and catalysis are now being unravelled, with practical implications for the design of antibiotics. 

Driving ribosome assembly.

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Analysis of rpS assembly status in two mutants in which pre-SSU nuclear export is blocked and one in which export is strongly delayed show that key aspects of the in vivo assembly of eukaryotic r-proteins into distinct structural parts of the SSU are similar to the in vitro assembly pathway of their prokaryotic counterparts.

The nucleoid as a site of rRNA processing and ribosome assembly

Little is known about the spatial organization of the procedure in bacteria and organelles, but ribosomal composition and many mechanistic aspects of their biogenesis are well understood.



Ribosome synthesis in Saccharomyces cerevisiae.

The recent, and often surprising, advances in the understanding of ribosome synthesis in the yeast Saccharomyces cerevisiae will underscore the unexpected complexity of eukaryotic ribosomes synthesis.

Atomic structures at last: the ribosome in 2000.

Structure of Functionally Activated Small Ribosomal Subunit

The small ribosomal subunit performs the decoding coding mechanism and its universality, and highlights of genetic information during translation, and shows known as well as newly detected folding and packing motifs.

Reconstitution of 50S Ribosomal Subunits from Dissociated Molecular Components

50S ribosomal subunits of Bacillus stearothermophilus have been reconstituted by incubating their RNA and protein components at high temperatures.

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The mechanism of peptide bond synthesis constitutes a fundamental and long-debated question in molecular biology. For many years, ribosomologists championed a protein-based mechanism, similar to the

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