The fructose 1,6-diphosphatase-phosphofructokinase substrate cycle. A site of regulation of hepatic gluconeogenesis by glucagon.

The effect of glucagon on the rate of gluconeogenesis from substrates not involving pathways of mitochondrial metabolism has been investigated in isolated rat liver cells. From estimation of the rates of glucose formation, glucose phosphorylation, fructose 6-phosphate phosphorylation, fructose 1,6diphosphate dephosphorylation, and lactate and pyruvate… CONTINUE READING