The frequency of heterologous synapsis increases with aging in Robertsonian heterozygous male mice

@article{Vasco2011TheFO,
  title={The frequency of heterologous synapsis increases with aging in Robertsonian heterozygous male mice},
  author={Chiara Vasco and Marcia Manterola and Jes{\'u}s Page and Maurizio Zuccotti and Roberto de la Fuente and Carlo Alberto Redi and Ra{\'u}l Fern{\'a}ndez-Donoso and Silvia Garagna},
  journal={Chromosome Research},
  year={2011},
  volume={20},
  pages={269-278}
}
The house mouse is characterised by highly variable chromosome number due to the presence of Robertsonian (Rb) chromosomes. During meiosis in Rb heterozygotes, intricated chromosomal figures are produced, and many unsynapsed regions are present during the first prophase, triggering a meiotic silencing of unsynapsed chromatin (MSUC) in a similar mode to the sex chromosome inactivation. The presence of unsynapsed chromosome regions is associated with impaired spermatogenesis. Interestingly, in… CONTINUE READING

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