The frequency of hereditary large bowel cancer.

  title={The frequency of hereditary large bowel cancer.},
  author={John J. Mulvihill},
  journal={Progress in clinical and biological research},
In brief, an unknown but small fraction of colorectal cancer in the United States is due to single gene traits that are usually easy to identify by the clinician who is aware of the many disorders which predispose to colorectal cancer. An additional, perhaps a larger fraction could be attributed to familial cancer syndromes which may arise from environmental or genetic factors or both. In any case, once a familial or mendelian trait is recognized, the risk to offspring and sibs tends to be 50… CONTINUE READING