The frequency and distribution of apoptosis induced by three non-carcinogenic agents in mouse colonic crypts.

Abstract

The appearance of apoptotic cells has been used as an index of carcinogen-induced damage inflicted on the colonic epithelium. We report here that 3 potent biological toxins, colchicine, puromycin and diphtheria toxin which have not been shown to be carcinogenic cause a dose-related increase in apoptotic cells in the colonic epithelium of the mouse. The distribution of apoptosis along the crypt length is characteristic for each of the agents studied.

Cite this paper

@article{Duncan1984TheFA, title={The frequency and distribution of apoptosis induced by three non-carcinogenic agents in mouse colonic crypts.}, author={A. M. Duncan and John A. Heddle}, journal={Cancer letters}, year={1984}, volume={23 3}, pages={307-11} }