The frequencies of calcium oscillations are optimized for efficient calcium-mediated activation of Ras and the ERK/MAPK cascade.

@article{Kupzig2005TheFO,
  title={The frequencies of calcium oscillations are optimized for efficient calcium-mediated activation of Ras and the ERK/MAPK cascade.},
  author={Sabine Kupzig and Simon Walker and Peter J. Cullen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 21},
  pages={7577-82}
}
Ras proteins are binary switches that, by cycling through inactive GDP- and active GTP-bound conformations, regulate multiple cellular signaling pathways, including those that control growth and differentiation. For some time, it has been known that receptor-mediated increases in the concentration of intracellular free calcium ([Ca(2+)](i)) can modulate Ras activation. Increases in [Ca(2+)](i) often occur as repetitive Ca(2+) spikes or oscillations. Induced by electrical or receptor stimuli… CONTINUE READING