The free-radical scavenger edaravone accelerates thrombolysis with alteplase in an experimental thrombosis model.

@article{Yamashita2015TheFS,
  title={The free-radical scavenger edaravone accelerates thrombolysis with alteplase in an experimental thrombosis model.},
  author={Tsutomu Yamashita and Takumi Sato and Kumi Sakamoto and Hiromitsu Ishii and Junichiro Yamamoto},
  journal={Thrombosis research},
  year={2015},
  volume={135 6},
  pages={1209-13}
}
BACKGROUND AND PURPOSE Reperfusion injury after thrombolytic therapy can have adverse neurologic effects. The free-radical scavenger edaravone is used in combination with the recombinant tissue plasminogen activator alteplase to treat acute ischemic stroke. However, basic investigations of this combination use remain inadequate. Here, we used an in vivo model to investigate the effects of edaravone on alteplase-induced thrombolysis. METHODS Thrombolysis was evaluated by using a He-Ne-laser… CONTINUE READING