The frail elderly: role of dendritic cells in the susceptibility of infection.

  title={The frail elderly: role of dendritic cells in the susceptibility of infection.},
  author={Koichi Uyemura and Steven Charles Castle and Takashi Makinodan},
  journal={Mechanisms of ageing and development},
  volume={123 8},
The decline in immunity in the elderly has largely been attributed to impairment of T cell mechanisms. This seems reasonable since the thymus involutes with age, so that the number of naïve cells to respond to new foreign antigens also declines. However, little is known about how aging affects antigen-presenting cells (APC) that are responsible for the initiation and outcome of effector T cell immune responses. This review focuses on the age-related alterations of a key APC, the dendritic cell… CONTINUE READING


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