The fragile-X syndrome, IV. Progress towards the identification of linked restriction fragment length variants (RFLVs).

@article{Holden1984TheFS,
  title={The fragile-X syndrome, IV. Progress towards the identification of linked restriction fragment length variants (RFLVs).},
  author={J. A. Holden and Hong-rui Wang and B. N. White},
  journal={American journal of medical genetics},
  year={1984},
  volume={17 1},
  pages={259-73}
}
We present our strategy and progress towards the identification of rare restriction fragment length variants (RFLVs) segregating with the fragile-X syndrome. DNA from a carrier mother and two retarded sons was digested with 7 restriction endonucleases and Southern blots were probed with cloned unique X-chromosomal sequences. Two of 17 cloned segments tested revealed RFLVs between the X-chromosomes of the carrier mother. One of them detected variants using Pvu II and Msp I. The Pvu II and Msp I… CONTINUE READING