The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals.

@article{Eberhart1996TheFX,
  title={The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals.},
  author={Derek E. Eberhart and Henry E. Malter and Ywan Feng and Stephen T Warren},
  journal={Human molecular genetics},
  year={1996},
  volume={5 8},
  pages={
          1083-91
        }
}
Fragile X syndrome is a frequent cause of mental retardation resulting from the absence of FMRP, the protein encoded by the FMR1 gene. FMRP is an RNA-binding protein of unknown function which is associated with ribosomes. To gain insight into FMRP function, we performed immunolocalization analysis of FMRP truncation and fusion constructs which revealed a nuclear localization signal (NLS) in the amino terminus of FMRP as well as a nuclear export signal (NES) encoded by exon 14. A 17 amino acid… CONTINUE READING

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