The fraction of cells in G1 with bound retinoblastoma protein increases with the duration of the cell cycle.

@article{Jonassen1994TheFO,
  title={The fraction of cells in G1 with bound retinoblastoma protein increases with the duration of the cell cycle.},
  author={T S Jonassen and Per O. Seglen and Trond Stokke},
  journal={Cell proliferation},
  year={1994},
  volume={27 2},
  pages={
          95-104
        }
}
The retinoblastoma gene product (pRB) is a nuclear phosphoprotein with growth-suppressing effects. During early G1 phase, pRB is underphosphorylated and bound in the nucleus. The association between the duration of the cell cycle/G1 phase and the fraction of cells in G1 with bound pRB was studied in the human pre-B cell line Reh. The cell-cycle duration was varied by growing cells at different concentrations (25, 10, 2, 0.5 and 0%) of fetal calf serum (FCS); pRB binding was studied by flow… CONTINUE READING
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