The four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity.

@article{Lam2010TheFC,
  title={The four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity.},
  author={Wing Lam and Scott Bussom and Fulan Guan and Zaoli Jiang and Wei Zhang and Elizabeth A. Gullen and Shwu-Huey Liu and Yung-chi Cheng},
  journal={Science translational medicine},
  year={2010},
  volume={2 45},
  pages={45ra59}
}
PHY906, a four-herb Chinese medicine formula first described 1800 years ago, decreases gastrointestinal toxicity induced by the chemotherapeutic drug CPT-11 (irinotecan), as shown in a phase I/II clinical study. Similarly, in a murine colon 38 allograft model, PHY906 increased the antitumor activity of CPT-11 while decreasing animal weight loss caused by CPT-11. Here, we have further examined the effect of PHY906 on the intestinal toxicity caused by CPT-11 in mice. PHY906 did not protect… CONTINUE READING
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Irinotecan can significantly change the pharmacokinetics and pharmacodynamics of PHY906, a Chinese medicine formulation for cancer therapy

  • M. Ye, Z. Jiang, +6 authors A novel herb-drug interaction
  • Proc. Am. Assoc. Cancer Res. 49
  • 2008
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